Objective To analyze and define the concept of psychological insulin resistance in diabetic patients by Walker and Avant conceptual analysis method. Methods We systematically searched PubMed,Cochrane Library,Web of Science,Embase,CINAHL, CNKI, VIP, Wanfang,CBM and other databases. Walker and Avant conceptual analysis framework was applied to analyze psychological insulin resistance in terms of concept definition,concept attributes,antecedents,consequences and assessment tools. Results A total of 89 literatures related to psychological insulin resistance were included. Psychological insulin resistance in patients with diabetes included three attributes:negative psychology,misperceptions,and inadequate coping. The antecedents factors included patients-related factors,factors related to insulin treatment,and supportive factors. Conclusion Clarifying the concept of psychological insulin resistance in diabetic patients through the Walker and Avant conceptual analysis method can help medical staffs raise awareness and identify psychological insulin resistance more easily. In addition,it can provide reference for researchers to conduct further related studies.