With the continuous growth of medical demands and the increasing complexity of the medical system,advanced practice nurses(APNs) are playing an increasingly important role in improving the quality of medical services and optimizing the allocation of resources. This article summarizes the training characteristics of APN abroad and combines the training experience of APN in West China Hospital of Sichuan University to share thoughts on the training model of core competencies of APN. Currently,the development of advanced practical talent cultivation models at home and abroad shows diversified paths. In the future,it is necessary to continue to integrate local demands and international experiences,strengthen the exploration of advanced core ability cultivation models for APN talents,and provide references for cultivating more high-quality APN talents in China to meet the growing health needs of the people.