多发性骨髓瘤患者康复护理中运动干预的范围综述

doi:10.3761/j.issn.1672-9234.2026.08.018

摘要/Abstract

摘要：

目的了解文献中针对多发性骨髓瘤患者的运动干预要素，为制订标准化多发性骨髓瘤患者运动方案提供参考。方法基于Arksey和O’Malley提出的范围综述框架，系统检索中国知网、维普、万方数据库、中国生物医学文献数据库、PubMed、Embase、the Cochrane Library、Web of Science数据库，检索时间为建库至2025年7月4日，对纳入文献进行筛选、资料提取。结果共纳入18篇文献，多发性骨髓瘤患者运动干预内容包括运动前的准备、运动的类型、运动的场所、运动时间和频率、运动强度、干预周期、运动强度的监测方式、结局指标等。结论现有研究方案在运动干预类型、运动强度、运动频率和时间方面存在较大的异质性，但均表明了运动干预对患者的积极影响。未来研究应依据患者病情、体能及身体状况制订科学的个性化多发性骨髓瘤患者运动干预方案。

关键词: 多发性骨髓瘤, 运动, 范围综述, 康复护理

Abstract:

Objective To identify the key components of exercise interventions for patients with multiple myeloma as reported in the literature，thereby providing a reference for developing standardized exercise programs for these patients. Methods Based on Arksey and O’Malley’s scoping review framework，we systematically in databases including CNKI，VIP，Wanfang，SinoMed，PubMed，Embase，the Cochrane Library，and Web of Science. The search time was from database inception to July 4，2025，and two researchers screened and extracted data from the literature. Results A total of 18 articles were included. The content of exercise intervention for multiple myeloma patients included preparation before intervention，types of exercise，exercise venues，exercise time，frequency，intensity，intervention period，monitoring methods of exercise intensity，outcome indicators，and intervention effects. Conclusion Existing research protocols show significant heterogeneity in terms of exercise intervention types，intensity，frequency and duration，yet all demonstrate the positive effects of exercise interventions on patients. Future studies should formulate scientific，personalized exercise intervention programs for multiple myeloma patients based on their disease condition，physical fitness and physical status.

Key words: Multiple Myeloma, Exercise, Scoping Review, Rehabilitation Nursing

肖永凤, 张英. 多发性骨髓瘤患者康复护理中运动干预的范围综述[J]. 中华护理教育, 2026, 23(8): 1019-1025.

XIAO Yongfeng, ZHANG Ying. Exercise intervention in rehabilitation nursing for multiple myeloma patients：a scoping review[J]. Chinese Journal of Nursing Education, 2026, 23(8): 1019-1025.

图/表 1

参考文献 28

[1]	Wefelnberg MM, Niels T, Holtick U, et al. Clinical exercise therapy program with multiple myeloma patients:impacts on feasibility,adherence and efficacy[J]. Support Care Cancer, 2022, 30(11):9615-9623. doi: 10.1007/s00520-022-07369-9 pmid: 36190557
[2]	中国临床肿瘤学会指南工作委员会. 多发性骨髓瘤骨病临床诊疗专家共识(2021)[J]. 临床肿瘤学杂志, 2022, 27(1):65-72.
	Guidelines Committee of Chinese Society of Clinical Onco-logy. Chinese expert consensus on the diagnosis and mana-gement of multiple myeloma-related bone disease(version 2021)[J]. Chin Clin Oncol, 2022, 27(1):65-72.
[3]	Zaleta AK, Miller MF, Olson JS, et al. Symptom burden,perceived control,and quality of life among patients living with multiple myeloma[J]. J Natl Compr Cancer Netw, 2020, 18(8):1087-1095.
[4]	Ramsenthaler C, Osborne TR, Gao W, et al. The impact of di-sease-related symptoms and palliative care concerns on health-related quality of life in multiple myeloma:a multi-centre study[J]. BMC Cancer, 2016, 16:427. doi: 10.1186/s12885-016-2410-2 pmid: 27387201
[5]	Joshy G, Thandrayen J, Koczwara B, et al. Disability,psycholo-gical distress and quality of life in relation to cancer diag-nosis and cancer type:population-based Australian study of 22,505 cancer survivors and 244,000 people without cancer[J]. BMC Med, 2020, 18(1):372. doi: 10.1186/s12916-020-01830-4
[6]	Hillengass RN ACSM-CPT M, Joseph MS MBA J, McCarthy J, et al. Physical activity in multiple myeloma:a review of the current literature[J]. J Adv Pract Oncol, 2023, 14(2):153-158. doi: 10.6004/jadpro.2023.14.2.5 pmid: 37009406
[7]	Nicol JL, Woodrow C, Burton NW, et al. Physical activity in people with multiple myeloma:associated factors and exercise program preferences[J]. J Clin Med, 2020, 9(10):3277. doi: 10.3390/jcm9103277
[8]	Arksey H, O’Malley L. Scoping studies:towards a methodolo-gical framework[J]. Int J Soc Res Methodol, 2005, 8(1):19-32. doi: 10.1080/1364557032000119616
[9]	徐丽珍, 孙彩虹, 杜锋蔚, 等. EXCAP锻炼在多发性骨髓瘤化疗所致周围神经病变患者中的应用研究[J]. 护理与康复, 2023, 22(2):12-19.
	Xu LZ, Sun CH, Du FW, et al. Research on application of exercise for cancer patients on chemotherapy-induced periphe-ral neuropathy for patients with multiple myeloma[J]. Nurs Rehabil J, 2023, 22(2):12-19.
[10]	王进, 郝新宝. EXCAP锻炼在多发性骨髓瘤化疗所致周围神经病变患者中的应用[J]. 饮食保健, 2024(1):33-36.
	Wang J, Hao XB. Application of EXCAP exercise in patients with chemotherapy-induced peripheral neuropathy in multiple myeloma[J]. Diet Health, 2024(1):33-36.
[11]	朱丽, 赵引丽, 田丹丹, 等. 家庭支持个体化运动计划对老年多发性骨髓瘤患者疲劳、睡眠和日常行为的影响[J]. 老年医学与保健, 2022, 28(5):1136-1141.
	Zhu L, Zhao YL, Tian DD, et al. Effects of family-supported individualized exercise program on fatigue,sleep,and daily beha-vior in elderly patients with multiple myeloma[J]. Geriatr Health Care, 2022, 28(5):1136-1141.
[12]	仲伟莹, 汤芳, 徐岚, 等. 肢体运动训练对多发性骨髓瘤化疗致周围神经病变患者的影响[J]. 护理学杂志, 2024, 39(2):101-104.
	Zhong WY, Tang F, Xu L, et al. Effect of limb movement training in multiple myeloma patients with chemotherapy-induced peripheral neuropathy[J]. J Nurs Sci, 2024, 39(2):101-104.
[13]	Hillengass J, Hillengass M, Joseph JM, et al. Effects on the physical functioning of two exercise interventions in patients with multiple myeloma:a pilot feasibility study[J]. Cancers, 2024, 16(9):1774. doi: 10.3390/cancers16091774
[14]	Larsen RF, Jarden M, Minet LR, et al. Exercise in newly diag-nosed patients with multiple myeloma:a randomized control-led trial of effects on physical function,physical activity,lean body mass,bone mineral density,pain,and quality of life[J]. European J Haematology, 2024, 113(3):298-309. doi: 10.1111/ejh.v113.3
[15]	Czerwińska-Ledwig O, Żychowska M, Jurczyszyn A, et al. The impact of a 6-week Nordic walking training cycle and a 14-hour intermittent fasting on disease activity markers and serum levels of Wnt pathway-associated proteins in patients with multiple myeloma[J]. J Clin Med, 2024, 13(10):2771. doi: 10.3390/jcm13102771
[16]	Nicol JL, Cunningham BJ, Woodrow C, et al. Safety,feasibility,and acceptability of a multisite individualized exercise inter-vention for people with multiple myeloma[J]. Med Sci Phys Exerc, 2023, 55(12):2214-2227.
[17]	Czerwińska-Ledwig O, Jurczyszyn A, Piotrowska A, et al. The effect of a six-week Nordic walking training cycle on oxida-tive damage of macromolecules and iron metabolism in older patients with multiple myeloma in remission:randomized cli-nical trial[J]. Int J Mol Sci, 2023, 24(20):15358. doi: 10.3390/ijms242015358
[18]	Czerwińska-Ledwig O, Vesole DH, Piotrowska A, et al. Effect of a 6-week cycle of Nordic walking training on vitamin 25(OH)D₃ calcium-phosphate metabolism and muscle damage in multiple myeloma patients-randomized controlled trial[J]. J Clin Med, 2022, 11(21):6534. doi: 10.3390/jcm11216534
[19]	Nicol JL, Woodrow C, Cunningham BJ, et al. An individualized exercise intervention for people with multiple myeloma-study protocol of a randomized waitlist-controlled trial[J]. Curr Oncol, 2022, 29(2):901-923. doi: 10.3390/curroncol29020077 pmid: 35200576
[20]	Koutoukidis DA, Land J, Hackshaw A, et al. Fatigue,quality of life and physical fitness following an exercise intervention in multiple myeloma survivors(MASCOT):an exploratory rando-mised Phase 2 trial utilising a modified Zelen design[J]. Br J Cancer, 2020, 123(2):187-195. doi: 10.1038/s41416-020-0866-y
[21]	Larsen RF, Jarden M, Minet LR, et al. Supervised and home-based physical exercise in patients newly diagnosed with multiple myeloma:a randomized controlled feasibility study[J]. Pilot Feasibility Stud, 2019, 5(1):130. doi: 10.1186/s40814-019-0518-2
[22]	McCourt O, Fisher A, Ramdharry G, et al. Exercise prehabili-tation for people with myeloma undergoing autologous stem cell transplantation:results from PERCEPT pilot randomised controlled trial[J]. Acta Oncol, 2023, 62(7):696-705. doi: 10.1080/0284186X.2023.2178326
[23]	Emery A, Moore S, Crowe J, et al. The effects of short-term,progressive exercise training on disease activity in smoul-dering multiple myeloma and monoclonal gammopathy of undetermined significance:a single-arm pilot study[J]. BMC Cancer, 2024, 24(1):174. doi: 10.1186/s12885-024-11817-6 pmid: 38317104
[24]	McCourt O, Fisher A, Ramdharry G, et al. PERCEPT myelo-ma:a protocol for a pilot randomised controlled trial of exercise prehabilitation before and during autologous stem cell transplantation in patients with multiple myeloma[J]. BMJ Open, 2020, 10(1):e033176. doi: 10.1136/bmjopen-2019-033176
[25]	Lee K, Nathwani N, Shamunee J, et al. Telehealth exercise to Improve Physical function and frailty in patients with multi-ple myeloma treated with autologous hematopoietic Stem cell transplantation(TIPS):protocol of a randomized controlled trial[J]. Trials, 2022, 23(1):921. doi: 10.1186/s13063-022-06848-y
[26]	Groeneveldt L, Mein G, Garrod R, et al. A mixed exercise train-ing programme is feasible and safe and may improve quality of life and muscle strength in multiple myeloma survivors[J]. BMC Cancer, 2013, 13(1):31. doi: 10.1186/1471-2407-13-31
[27]	Larsen RF, Jarden M, Minet LR, et al. Physical function in patients newly diagnosed with multiple myeloma;a Danish cohort study[J]. BMC Cancer, 2020, 20(1):169. doi: 10.1186/s12885-020-6637-6 pmid: 32126972
[28]	Purdy GM, Venner CP, Tandon P, et al. Feasibility of a tailo-red and virtually supported home exercise program for people with multiple myeloma using a novel eHealth application[J]. Digit Health, 2022, 8:205520762211290.