Abstract:

Objective To analyze the difference in the effect of aerobic exercise on knee osteoarthritis（KOA） through network meta-analysis，so as to provide the evidence for clinical doctors and nurses in selecting the type of aerobic exercise. Methods The databases of CNKI，Wanfang，VIP，SinoMed，PubMed，Web of Science，Embase and Cochrane Library were systematically searched to collect randomized controlled trial（RCT） of aerobic exercise intervention in patients with knee osteoarthritis. The retrieval time limit was set from the establishment of the database to November 2022. Two trained researchers independently screened the literature，extracted unqualified data，and evaluated the quality of the included studies using the RCT bias risk assessment tool recommended by Cochrane evidence-based center. Stata 15.0 software was employed for network meta-analysis. Results A total of 21 studies were included，covering 1 209 KOA patients. The results of network meta-analysis showed that the effect of aquatic running and walking was better than that of conventional treatment（P<0.05） in relieving pain of KOA patients，and aquatic running was the best（SUCRA=87.1%）. The comparison of intervention effects on aerobic exercise in stiffness and joint function displayed no statistical difference（P>0.05）. Meanwhile，the first place of SUCRA in stiffness and joint function was bicycle （77.3%） and walking（79.3%）. Conclusion The current evidence showed that aquatic running demonstrated to be the best way to relieve pain of KOA patients，bicycle might be the best way to relieve stiffness，and walking might be the best way to improve function. Limited by the number and quality of included studies，the current conclusions are still need to be further verified by more high-quality studies.

Key words: Exercise Therapy, Osteoarthritis，Knee, Evidence-Based Nursing, Pain, Rigidity, Joint dysfunction