Abstract:

Objective To systematically summarize the best evidence on medication interruption management in nursing and provide guidance for clinical practice. Methods Following the “5S” evidence-based model，researchers systematically searched Chinese and English databases，guideline-related websites，and interruptions.net for literature related to medication interruption management，including clinical decision-making，best practices，clinical practice guidelines，systematic reviews，evidence summaries，expert consensus，and original research. The search period was from the establishment of the database to December 31，2024. Two researchers trained in systematic evidence-based knowledge independently conducted literature screening，quality assessment，evidence extraction，and synthesis based on clear inclusion and exclusion criteria. Results A total of 33 studies were finally included，comprising two systematic reviews，three randomized controlled trials，and 28 quasi-experimental studies. Seventeen recommendations were derived from three dimensions：organizational level（5 items），management level（7 items），and individual level （5 items），covering key elements such as standardized workflows，environmental optimization，multidisciplinary collaboration，and medication interruption management training. Conclusion Based on the existing evidence，it is recommended to optimize the medication safety environment，establish a medication safety management system，enhance medication interruption management training，and conduct interruption management education for patients and families to effectively reduce the incidence of medication errors related to interruptions and ensure patient medication safety.

Key words: Medication Interruptions Management, Safety Management, Evidence-Based Nursing, Evidence Summary