Abstract: Objective To translate the Acromegaly Quality of Life Questionnaire （AcroQoL） into Chinese，and to test its psychometric properties in Chinese patients. Methods The forward and backward translation were per-formed and the Chinese version of AcroQoL was finalized. An expert panel （n=5） was used to evaluate the content validity of the instrument. A total of 150 patients were recruited by convenience sampling to test the psychometric properties of the Chinese version of AcroQoL. Results The content validity index of the Chinese version of Acro-QoL was 0.93. Three factors，which were physical health，appearance issues and personal relations，were extracted by exploratory factor analysis and they could explain 64.02% of total variance.Cronbach’s α coefficient for the overall scale was 0.929 and the retest reliability was 0.850. Conclusion The Chinese version of the AcroQoL has good validity and reliability，and can be used objectively to evaluate the health related quality of life of patients with acromegaly.

Key words: Acromegaly, Quality of Life, Instrument, Reliability, Validity