Abstract:

Objective To explore the impact of chemotherapy-induced peripheral neuropathy and its predictors on psychological well-being among cancer patients based on the Theory of Unpleasant Symptoms. Methods A cross-sectional survey was conducted with 302 cancer patients from one tertiary hospitals. Patients were assessed with questionnaires of Patient Health Questionnaire-9,Perceived Social Support Scale,Chemotherapy-induced Peripheral Neuropathy Assessment Tool,and Functional Assessment of Cancer Therapy-General from July 2018 to July 2019. Results Cancer stage（β=0.09,P=0.016）,depression（β=0.70,P<0.001）and social support（β=-0.11,P<0.001）had a direct effect on chemotherapy-induced peripheral neuropathy,and chemotherapy-induced peripheral neuropathy had a direct effect on quality of life（β=-0.83,P<0.001）. Cancer stage,depressionand social support had significant indirect effects on quality of life. Conclusion Cancer stage,depression and social support are the main factors affecting the chemotherapy-induced peripheral neuropathy,and these predictors have significant indirect impact on quality of life among cancer patients,which is of great significance for controlling the incidence of chemotherapy-induced peripheral neuropathy and improving the quality of life of cancer patients.

Key words: Maintenance Chemotherapy, Peripheral Nerves, Depression, Social Support, Quality of Life, Maintenance Chemotherapy, Peripheral Nerves, Depression, Social Support, Quality of Life