ISSN 1672-9234　CN 11-5289/R
主管：中国科学技术协会　主办：中华护理学会
出版：中华护理杂志社
收录：中国科学引文数据库（CSCD）来源期刊
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　　　中国核心期刊（遴选）数据库
　　　中文科技期刊数据库
中华护理教育

中华护理教育 ›› 2019, Vol. 16 ›› Issue (12): 892-896.

• 慢性病管理专题 • 上一篇    下一篇

癌症患者化疗所致周围神经病变及影响因素分析

洪悦颖 徐晨 于海燕 李晓莹 王琪 任丽萍   

  1. 济宁医学院护理学院
  • 出版日期:2019-12-20 发布日期:2020-01-07

Prevalence and predictors of chemotherapy-induced peripheral neuropathy in patients with cancer

HONG Yue-ying，XU Chen，YU Hai-yan，LI Xiao-ying，WANG Qi，REN Li-ping   

  • Online:2019-12-20 Published:2020-01-07

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摘要： 目的 调查癌症患者化疗所致周围神经病变的现状，以不愉快症状理论为框架探讨其影响因素。 方法 2017年7月-2018年7月选取某三级甲等医院进行化疗的254例癌症患者为研究对象，采用一般资料调查表、化疗所致周围神经病变评估工具、患者健康状况问卷及领悟社会支持量表对癌症患者进行问卷调查。 结果 化疗所致周围神经病变发生率为74.02%。 多元线性回归分析显示，癌症分期、抑郁、社会支持是癌症患者发生化疗所致周围神经病变的影响因素，共同解释化疗所致周围神经病变变异的53.4%。 结论 癌症患者化疗所致周围神经病变的发生率处于较高水平，护士应重视患者的抑郁和社会支持情况，为患者制订整体护理干预方案，提高患者生活质量。

Abstract: Objective To investigate the prevalence of chemotherapy-induced peripheral neuropathy among cancer patients，and to explore the predictors based on the theory of unpleasant symptoms. Methods A total of 254 can-cer patients recruited from one tertiary hospital by convenience sampling from July 2017 to July 2018 were assessed with questionnaires of Chemotherapy-induced Peripheral Neuropathy Assessment Tool(CIPNAT)，Patient Health Ques-tionnaire-9(PHQ-9)and Perceived Social Support Scale(PSSS). Results The prevalence of chemotherapy-induced peripheral neuropathy was 74.02%. Multiple linear regression showed that cancer stage，depression and social support could explain 53.4% of the total variation of chemotherapy-induced peripheral neuropathy among cancer patients. Conclusion The prevalence of chemotherapy-induced peripheral neuropathy in patients with cancer is on a high level. Nurses should pay attention to patients’ depression and social support，make nursing intervention plans for patients, and improve their quality of life.