Objective To evaluate the effect of health education on disease-related knowledge and safe sex in patients with sexually transmitted diseases(STD). Methods Seven nurses received professional knowledge and skills training and they provided health education on STD-related knowledge and safe sex,psychological interventions and follow-up service for 362 STD patients in the private consulting room. Results After intervention,the patients?蒺 knowledge related to the relapse,risk factors,prevention and consequences of STD increased significantly(P<0.01);their willingness to use condoms increased from 8.01% to 51.66%;the proportion having sex behaviors with spouse increased from 15.19% to 40.88%,with regular sex partner increased from 23.48% to 33.98%,with commercial partners decreased from 31.49% to 11.05%(P<0.01). Conclusion Health education can effectively improve the disease-related knowledge and promote safe sex behaviors in STD patients.