Abstract:

Objective To understand the current research status of exercise combined with cognitive training（ECT）in patients with mild cognitive impairment or Alzheimer’s disease. Methods We synthesized the studies according to the integrated review framework proposed by Whittemore and Knafl. Results A total of 33 articles from 28 studies were included. This review divided the combination modes of ECT into three types:dual-task,interactive and sequential types. Different modalities had various research schemes:the dual-task mode had the longest duration and the forms of interventions were relatively simple;the interactive mode was similar with dual-task mode in frequency and the duration of each session. Most studies of interactive mode adopted aerobic exercise combined with computer games. The sequential mode had the longest weekly time and the most frequency,and the forms of exercise and cognitive training were relatively complex. In addition,the review found that 18 articles（72.0%） from 25 studies with control group were dual-arm,and 13 articles（46.4%） reported adherence rates. Effectiveness evaluation indicators included cognitive function,psycho-behavioral symptoms,activities of daily living,quality of life,gait,etc. Conclusion The intervention schemes need to be further standardized. Future studies should pay more attention to reasonable control group,adherence,and objective indicators.

Key words: Exercise, Cognitive Therapy, Alzheimer Disease, Mild Cognitive Impairment, Integrated review