癌症相关认知障碍发生率及影响因素的系统评价

doi:10.3761/j.issn.1672-9234.2025.05.018

摘要/Abstract

摘要：

目的系统评估癌症相关认知障碍的发生率及影响因素。方法检索PubMed、Embase、Web of Science、Cochrane Library、中国生物医学文献数据库、中国知网、万方和维普数据库，从建库至2024年12月有关癌症相关认知障碍影响因素的所有文献，由2名评价人员按照标准独立筛选文献、提取资料、评价文献质量。采用Stata 16软件对资料进行Meta分析。结果共纳入20篇文献，Meta分析结果显示，癌症相关认知障碍发生率为31%，年龄、学历、睡眠、化疗、放疗、糖尿病、抑郁和焦虑是癌症相关认知障碍的影响因素。结论癌症相关认知障碍发生率高，且其发生受社会人口学、生活方式、临床因素、心理因素的影响，医护人员应早期识别癌症相关认知障碍高危群体，并通过制订、实施针对性的干预措施，减少癌症相关认知障碍的发生，减轻癌症相关认知障碍的不良影响。

关键词: 肿瘤, 癌症相关认知障碍, 发生率, 影响因素, 系统评价

Abstract:

Objective To identify the incidence and influencing factors of cancer-related cognitive impairment by systematic review. Methods Databases were searched for all literatures on the influencing factors of cancer-related cognitive impairment from the establishment of the database to December 2024 including PubMed，Embase，Web of Science，Cochrane Library，SinoMed，CNKI，Wanfang Database and VIP. After that，two evaluators independently screened the literature according to the criteria，extracted the data，and evaluated the quality of the literature. Meta-analysis was performed using Stata 16 software. Results A total of 20 articles were included. The results of meta-analysis showed that the incidence of cancer-related cognitive impairment was 31%. In addition，age，education，sleep，chemotherapy，radiotherapy，diabetes，depression and anxiety were the influencing factors of cancer-related cognitive impairment. Conclusion The incidence of cancer-related cognitive impairment is high，and its occurrence is affected by social demographic character，lifestyle，clinical factors and psychological factors. Medical staff should identify high-risk groups of cancer-related cognitive impairment early，and reduce the occurrence of cancer-related cognitive impairment and cancer by formulating and implementing targeted intervention measures.

Key words: Cancer, Cancer-related cognitive impairment, Incidence, Influencing factors, Systematic review

姚佳盈, 赵梦琴, 朱慧, 李英, 王俊辉, 沈欣怡, 刘婷婷, 浦丽敏, 陈肖敏. 癌症相关认知障碍发生率及影响因素的系统评价[J]. 中华护理教育, 2025, 22(5): 623-629.

YAO Jiaying, ZHAO Mengqin, ZHU Hui, LI Ying, WANG Junhui, SHEN Xinyi, LIU Tingting, PU Limin, CHEN Xiaomin. Systematic review of prevalence and its influencing factors in patients with cancer-related cognitive impairment[J]. Chinese Journal of Nursing Education, 2025, 22(5): 623-629.

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