维持性血液透析患者疲乏发生率及影响因素的系统评价

doi:10.3761/j.issn.1672-9234.2023.11.018

摘要/Abstract

摘要：

目的系统评价维持性血液透析（maintenance hemodialysis，MHD）患者疲乏发生率及其影响因素。方法检索PubMed、Embase、Web of Science、Cochrane Library、CINAHL、中国生物医学文献数据库、中国知网、维普和万方数据库关于MHD患者疲乏发生率和（或）其影响因素的研究，检索时限为建库至2022年12月。由2名研究员独立筛选文献、提取资料并进行质量评价，采用Stata 17软件进行数据分析。结果共纳入18篇文献，包括7 695例研究对象。Meta分析结果显示，MHD患者疲乏发生率为64.0%[95%CI（0.58，0.70）]。血清白蛋白、睡眠质量、性别、透析龄、超滤量、焦虑情况、抑郁情况、年龄为MHD患者疲乏的影响因素（均P<0.05）。结论 MHD患者疲乏发生率高且影响因素较多，医护人员应针对疲乏发生的可干预影响因素积极采取护理措施，早期预防MHD患者疲乏的发生，以提高患者生活质量。

关键词: 血液透析滤过, 疲乏, 影响因素, 系统评价

Abstract:

Objective To evaluate the incidence of fatigue and its influencing factors in patients with maintenance hemodialysis（MHD）. Methods PubMed，Embase，Web of Science，Cochrane Library，CINAHL，SinoMed CNKI，VIP and Wangfang were searched from inception to December 2022，aiming to collect studies on the prevalence of fatigue and its risk factors in patients with MHD. Two researchers independently conducted literature screening then data extraction and quality evaluation were conducted according to the standards. Stata 17 software was used for carrying out the meta-analysis of incidence and influencing factors. Results A total of 18 studies were included，involving 7 695 cases of MHD. The results of meta-analysis showed that the incidence of fatigue was 64.0% [95%CI（0.58，0.70）]. Serum albumin，sleep quality，gender，duration of dialysis，ultrafiltration capacity，anxiety，depression，and age were the influencing factors of fatigue in MHD patients（all P<0.05）. Conclusion The prevalence of fatigue in patients with MHD is high and there are many influencing factors. Medical workers should provide targeted intervention for them according to the factors of fatigue，so as to help them prevent the occurrence of fatigue and improve the quality of life of patients.

Key words: Hemodiafiltration, Fatigue, Influence factors, Systematic review

张颖, 刘雪琴, 刘晓辉, 魏巍, 吴亚琪, 江啸, 章晓菲, 聂亚杰. 维持性血液透析患者疲乏发生率及影响因素的系统评价[J]. 中华护理教育, 2023, 20(11): 1391-1397.

ZHANG Ying, LIU Xueqin, LIU Xiaohui, WEI Wei, WU Yaqi, JIANG Xiao, ZHANG Xiaofei, NIE Yajie. Systematic review of fatigue prevalence and its influencing factors in patients with maintenance hemodialysis[J]. Chinese Journal of Nursing Education, 2023, 20(11): 1391-1397.

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