Chinese Journal of Nursing Education >
A pathway analysis of impact of chemotherapy-induced peripheral neuropathy and its predictors on quality of life among cancer patients
Objective To explore the impact of chemotherapy-induced peripheral neuropathy and its predictors on psychological well-being among cancer patients based on the Theory of Unpleasant Symptoms. Methods A cross-sectional survey was conducted with 302 cancer patients from one tertiary hospitals. Patients were assessed with questionnaires of Patient Health Questionnaire-9,Perceived Social Support Scale,Chemotherapy-induced Peripheral Neuropathy Assessment Tool,and Functional Assessment of Cancer Therapy-General from July 2018 to July 2019. Results Cancer stage（β=0.09,P=0.016）,depression（β=0.70,P<0.001）and social support（β=-0.11,P<0.001）had a direct effect on chemotherapy-induced peripheral neuropathy,and chemotherapy-induced peripheral neuropathy had a direct effect on quality of life（β=-0.83,P<0.001）. Cancer stage,depressionand social support had significant indirect effects on quality of life. Conclusion Cancer stage,depression and social support are the main factors affecting the chemotherapy-induced peripheral neuropathy,and these predictors have significant indirect impact on quality of life among cancer patients,which is of great significance for controlling the incidence of chemotherapy-induced peripheral neuropathy and improving the quality of life of cancer patients.
Li-ping REN , Yong-fang WANG , Jun-bo JIAO , Mei REN , Chuan-kun ZHANG , Dong-qin GAO . A pathway analysis of impact of chemotherapy-induced peripheral neuropathy and its predictors on quality of life among cancer patients[J]. Chinese Journal of Nursing Education, 2020 , 17(12) : 1129 -1133 . DOI: 10.3761/j.issn.1672-9234.2020.12.015
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