Abstract:

Objective To systematically evaluate the incidence and related factors of apathy in Chinese stroke patients. Methods We searched PubMed，Embase，Web of Science，Cochrane Library，China Biomedical Literature Database，CNKI，VIP，and Wanfang databases for studies on the incidence of apathy in Chinese stroke patients and/or its related factors，with a search deadline from inception to January 2024. Two researchers independently screened the literature，extracted data，and assessed the bias risk. Data analysis was performed using Stata 12.0 and RevMan 5.3 software. Results A total of 20 articles involving 3，135 patients were included. Meta analysis results showed that the incidence of apathy in Chinese stroke patients was 35.0%. The influencing factors for apathy in stroke patients included a stroke history（OR=2.75），diabetes（OR=2.39），NIHSS score（OR=1.27），cognitive function（OR=0.80），activity of daily living（OR=0.87），depression（OR=1.14），homocysteine（OR=1.17），multiple lesions（OR=13.24），frontal lobe lesions（OR=10.25），brain stem lesions（OR=11.65），pontine lesions（OR=3.92），basal ganglia lesions（OR=5.26）（all P<0.05）. Conclusion The incidence of apathy in stroke patients in China is relatively high and there are many influencing factors. Medical staffs should pay special attention to high-risk populations and take early relevant intervention measures.

Key words: Stroke, Apathy, Prevalence, Related factors, Meta-analysis