癌症患者化疗致周围神经病变及相关因素对生活质量的影响

doi:10.3761/j.issn.1672-9234.2020.12.015

摘要/Abstract

摘要：

目的基于不悦症理论构建化疗致周围神经病变及其影响因素对癌症患者生活质量影响的路径模型,为制订癌症患者化疗致周围神经病变及生活质量的干预措施提供科学依据。方法 2018年7月—2019年7月选取某三级甲等医院进行化疗的302例癌症患者为研究对象,采用患者健康状况问卷、领悟社会支持量表、化疗致周围神经病变评估工具及癌症治疗功能评价量表对癌症患者进行调查。结果癌症分期（β=0.09,P=0.016）、抑郁（β=0.70,P<0.001）、社会支持（β=-0.11,P<0.001）对化疗致周围神经病变有直接效应;化疗致周围神经病变对生活质量有直接效应（β=-0.83,P<0.001）;癌症分期、抑郁及社会支持通过化疗致周围神经病变对生活质量有间接效应。结论癌症分期、抑郁、社会支持是化疗致周围神经病变的影响因素,并对生活质量有间接效应,可为干预化疗致周围神经病变及提高患者生活质量提供理论依据。

关键词: 维持化疗, 周围神经, 抑郁, 社会支持, 生活质量, 维持化疗, 周围神经, 抑郁, 社会支持, 生活质量

Abstract:

Objective To explore the impact of chemotherapy-induced peripheral neuropathy and its predictors on psychological well-being among cancer patients based on the Theory of Unpleasant Symptoms. Methods A cross-sectional survey was conducted with 302 cancer patients from one tertiary hospitals. Patients were assessed with questionnaires of Patient Health Questionnaire-9,Perceived Social Support Scale,Chemotherapy-induced Peripheral Neuropathy Assessment Tool,and Functional Assessment of Cancer Therapy-General from July 2018 to July 2019. Results Cancer stage（β=0.09,P=0.016）,depression（β=0.70,P<0.001）and social support（β=-0.11,P<0.001）had a direct effect on chemotherapy-induced peripheral neuropathy,and chemotherapy-induced peripheral neuropathy had a direct effect on quality of life（β=-0.83,P<0.001）. Cancer stage,depressionand social support had significant indirect effects on quality of life. Conclusion Cancer stage,depression and social support are the main factors affecting the chemotherapy-induced peripheral neuropathy,and these predictors have significant indirect impact on quality of life among cancer patients,which is of great significance for controlling the incidence of chemotherapy-induced peripheral neuropathy and improving the quality of life of cancer patients.

Key words: Maintenance Chemotherapy, Peripheral Nerves, Depression, Social Support, Quality of Life, Maintenance Chemotherapy, Peripheral Nerves, Depression, Social Support, Quality of Life

任丽萍, 王永芳, 焦俊博, 任梅, 张传坤, 高东芹. 癌症患者化疗致周围神经病变及相关因素对生活质量的影响[J]. 中华护理教育, 2020, 17(12): 1129-1133.

REN Li-ping, WANG Yong-fang, JIAO Jun-bo, REN Mei, ZHANG Chuan-kun, GAO Dong-qin. A pathway analysis of impact of chemotherapy-induced peripheral neuropathy and its predictors on quality of life among cancer patients[J]. Chinese Journal of Nursing Education, 2020, 17(12): 1129-1133.

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参考文献 24

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