Objective To explore the effects of standardized nursing program for patients with closed thoracic drainage. Methods The closed thoracic drainage quality control group was established and care of drainage tube was continuously improved according to the clinical problems. Therefore,a standardized nursing program for patients with closed thoracic drainage was gradually formed. Nurses were trained according to this program. The drainage nursing qualities between pre-implementation group（416 patients from January 2015 to October 2016） and post-implementation group（385 patients from November 2016 to July 2018）were compared. Results After the implementation of standardized nursing program,the rate of loose line,rate of drainage tube dropping off,rate of drainage tube fix,skin integrity,and knowledge were all significantly improved when compared with those before the program（P<0.05）. Conclusion The standardized nursing program can solve the problems and effectively improve the care quality of chest drainage tube.