Objective To examine the effects of teaching based on the forgetting rule in the course of Medical Nursing in a vocational college. Methods Class 7 and class 8 of grade 2015 in a vocational college were selected. They were randomly divided into the experimental group（n=52） and the control group（n=52） by drawing lots. The experimental group received repeated reviews based on the forgetting rule. The control group still use the traditional teaching method. The scores of the usual tests,mid-term exam and final exam were compared. Besides,a questionnaire survey was conducted in the experimental group. Results The test scores,the mid-term exam and the final exam of the experimental group were all higher than those of the control group（P<0.05）. The experimental group agreed that the method of strengthening memory by repeated reviews can improve learning initiative（82.7%）,learning efficiency（88.5%）,long-term memory（78.8%）,and help master key contents（88.5%）and knowledge systematically（82.7%）. Conclusion Teaching method based on forgetting rule can increase students’ long-term knowledge,improve their examination performance,and help students master Medical Nursing systematically.