This article summarized the perioperative care of a patient with chronic tonsillitis and IgA nephropathy after tonsillectomy. Psychological support was provided before the surgery. Explanations regarding the surgical process and possible complications after surgery were also provided. Close observation of bleeding after surgery and timely taking targeted nursing interventions were the main measures we took. Personalized diet and rational medication direction were given to the patient combining the dietary characteristics of patients with kidney disease to reduce kidney damage and promote wound healing. Detailed discharge education was conducted. After careful care,the patient was discharged 8 days after surgery.