Objective To explore the latent classes of live-space mobility trajectory and their influencing factors in COPD patients. Methods A prospective study was conducted on 179 COPD patients hospitalized at the First Affiliated Hospital of Zhejiang Chinese Medical University from January 2023 to February 2024. Life-space mobility was assessed at discharge（T0） and 1 month（T1），3 months（T2），6 months（T3），and 12 months（T4） post-discharge using the Live-Space Assessment. Latent class growth modeling was utilized to identify trajectory patterns，and multinomial Logistic regression was conducted to analyze influencing factors. Results The trajectory of life-space mobility of 179 COPD patients could be divided into three potential categories，namely the “low level-slow improvement group”（21.8%），the “medium level-improvement group”（55.3%），and the “medium level-progressive decline group”（22.9%）. Compared to “medium level-improvement group”，patients with COPD duration ≤5 years were less likely to fall into “low level-slow improvement group”，while those aged ≤70 years，extroverted personality types，no sedentary behavior，dyspnea index <3，and ≤2 acute exacerbations in the past year were less likely to enter “low level-slow improvement group” or “medium level-progressive decline group”（P<0.05）. Conclusion COPD patients exhibit heterogeneity in live-space mobility trajectories. Healthcare providers can develop targeted interventions based on the characteristics of these trajectories and relevant modifiable factors to improve live-space mobility levels.