Objective To explore the teaching design of Nursing Skills course in secondary vocational education and evaluate its practical effects. Methods The Nursing Skills course was designed by clarifying teaching objectives，integrating teaching content，constructing a “three-level，five-stage” teaching mode，building a teaching resource database，and devising an evaluation system. The curriculum was then implemented among 40 first-year nursing students in the 2022 cohort at Pinghu Vocational Secondary School. The teaching effectiveness was evaluated through course grades and student satisfaction surveys conducted through a self-designed questionnaire at the end of the course. Results The Nursing Skills course grades of the 40 students over three semesters were （88.08±3.34），（88.93±3.03），and（91.33±2.66），respectively. The proportion of students satisfied with teaching attitude，teaching ability，teaching content，teaching organization，acquisition of knowledge and skills，and clinical internship experience ranged from 77.5% to 92.5%. Conclusion The vocational nursing skills course demonstrated good teaching effectiveness，with high levels of student satisfaction. This study can provide a certain reference for teaching innovation in nursing programs in secondary vocational education.