Objective To explore the teaching design and practical effect of the Cross Frontier of Radiation Medicine Engineering and Nursing，so as to provide references for the construction of the multidisciplinary intersection training for nursing undergraduates in China. Methods A teaching plan for Cross Frontier of Radiation Medicine Engineering and Nursing was designed after defining teaching objectives，clarifying teaching contents and methods，and designing teaching evaluations. During the fall semester of 2023-2024 academic year，this teaching plan was applied among 26 second-year undergraduate nursing students who selected the course. After the course，a self-designed questionnaire was used to collect students’ opinions and suggestions on the teaching arrangement，content，and effect. Results The average course score among the 26 students was（91.5±3.2） points. According to the questionnaire results，73%（19/26） of the students believed that the teaching effect of the course teachers were excellent；96%（25/26） reported that their learning outcomes in this course were very good or relatively good，and 58%（15/26） indicated that the course has significantly enhanced their interdisciplinary thinking and ability to solve challenging nursing problems. Still，54%（14/26） and 50%（13/26） of the students suggested that the teaching effects in case analysis and group discussions required further improvement. Additionally，65%（17/26） of the students recommended enhancing their engagement through the introduction of case studies and simulated practice sessions. Conclusion The teaching of the Cross Frontier of Radiation Medicine Engineering and Nursing can achieve promising results，effectively fostering interdisciplinary thinking among nursing students. However，it is necessary to integrate student feedback and conduct further optimization of the course content，methodologies，and other aspects to further enhance its practical effect.