Objective To systematically evaluate and integrate the experience of nursing undergraduates about high-fidelity simulation teaching in order to provide references for improving the nursing teaching methods. Methods Databases were searched for qualitative studies on the experience of nursing undergraduates about high-fidelity simulation teaching including PubMed, Cochrane Library, Web of Science, Embase, CINAHL, PsycINFO, CNKI, Wanfang, VIP and SinoMed. The time limit was set from databases inception to June 2023. Results A total of nine studies were included, and 40 results were extracted. Results were summarized into seven categories and integrated into three synthesized findings：learning benefits and growth experience, the experience of role transformation, the negative experience in the teaching process. Conclusion Nursing undergraduates have a positive attitude and experience of high-fidelity simulation teaching. A safe, realistic teaching environment and learning experience for different roles is helpful for students to build up knowledge, promote the improvement of clinical comprehensive ability and improve nursing professional quality. While, the case operation and teaching content are still need to be improved.