Objective To explore the teaching practice and its effect of ideological and political education in the Fundamentals of Nursing. Methods The following measures had been taken to combine ideological and political elements with professional knowledge：clarifying curriculum ideological and political objectives，developing teaching design，constructing ideological and political teaching resource base，strengthening the construction of ideological and political teachers. From September 2021 to July 2022，a total of 118 second year nursing undergraduates were recruited as participants. After implementation，a course satisfaction questionnaire was used to evaluate students’ satisfaction with ideological and political education，impact on their willingness to engage in nursing work，and understand their learning experience. Results The overall satisfaction of students about ideological and political education in the Fundamentals of Nursing was 92%（109/118），with satisfaction rate of the permeation of various ideological and political elements between 75%-85%. Sixty-five students（55%） expressed stronger will to engage in nursing work. 93%（110/118） of the students reported that they gained something from the course’s ideological and political teaching. The course has been recognized as a top-notch provincial online and offline blended course. Conclusion The ideological and political education in the Fundamentals of Nursing has been affirmed by students，which is helpful to enhance students’ professional identity and ideological and political literacy，improve teachers’ ability，and promote to achieve the goal of "trinity" of value guidance，ability training and knowledge imparts.