Objective To explore a curriculum reform of Nursing Comprehensive Training based on the concept of "full integration of soft and hard skills"，drawing on the project of the National Vocational College Nursing Skills Competition. Methods Convenient sampling was employed with students in three classes of grade 2020 as the experimental group（n=136） and students in another three classes as the control group（n=138）. The teaching content of the experimental group was reformed based on the national vocational college nursing skills competition project，and online and offline mixed teaching based on teamwork were adopted. In teaching，while students’ hard skills were valued，soft skills such as communication，teamwork，problem-solving，and clinical thinking were also focused and trained. Meanwhile，traditional teaching methods were employed in the control group. The scores of OSCE（objective structured clinical examination） and the evaluations of the course were compared between the two groups. And the reflection diaries submitted by students in experimental group were analyzed to understand their learning experience. Results The OSCE scores of the experimental group[91.50（90.50，93.00）] were significantly better than those in the control group[82.25（80.00，84.50）]（P<0.001）. The students in the experimental group were significantly rated higher than those in the control group in the recognition of improving their practice confidence and nine types of soft and hard skills in the course（P<0.05）. Besides，the analysis of the reflective reports showed that students believed that this course had strong practicality and comprehensiveness with some difficulties and challenges，stimulated their learning initiative，and enhanced their comprehensive abilities and professional confidence. Conclusion The Nursing Comprehensive Training course based on Nursing Skills Competition effectively improves students’ hard and soft skills，which is conducive to the transition training from school learning to clinical practice.