Objective To explore the reform methods and teaching effects of online-offline blended teaching mode integrating medication nursing cases in the course of Nursing Pharmacology. Methods Nursing students in Class 1 of grade 2020 and 2021 were recruited as the participants and divided into the control group（n=53） and the experimental group（n=50）. While the control group adopted the traditional teaching method，the experimental group adopted the blended online-offline teaching mode with integrated medication nursing cases. At the end of the course，medication nursing core competency and independent learning ability of the two groups were compared. Results The self-learning ability and medication nursing core competency of the students in the experimental group were significantly higher compared with the control group（P<0.05）. Conclusion The blended teaching of nursing pharmacology based on case studies can improve teaching effect and be helpful in the training of self-learning ability for students in vocational college.