Objective To investigate factors promote and hinder the transforming of structured educational intervention program into clinical practice of gestational diabetes mellitus（GDM）. Methods The objective sampling method was employed to conduct semi-structured interviews with seven experts in obstetric care in a third-class A hospital. The interview outline was formulated according to the i-PARIHS framework，and the data was analyzed by Colaizzi 7-step analysis method and NVivo 12 software. Results After analysis，two themes and eight sub-themes were condensed from the interview data. Facilitating factors were as following. Firstly，clear curriculum plan will benefit clinical application and promotion. Besides，continuous follow-up will effectively consolidate the implementation effect. Also，clinical practice significance of the reform should be recognized by the medical staff. Still，the degree of participation and cooperation of patients to the reform is high. Meanwhile，hindrance factors were summarized include difficulty to carry out offline teaching in fixed groups. Multidisciplinary team cooperation mechanism needs to be optimized. Hospital diet fails to meet the needs of hospitalized GDM patients. Insufficient input of medical cost affects the implementation of reform. Conclusion For the program of "Structured Prenatal Education Course for GDM Patients"，the promotion factors at the reform level and the recipient level confirm the feasibility of the program’s clinical practice. Meanwhile，the hindrance factors at the recipient level and the organizational environment level suggest the necessity of program adjustment. In conclusion，it is necessary to pay attention to and correct the obstacle factors，further optimize the allocation of health education resources，and overcome and improve the obstacle factors from the management level in the process of clinical transformation of the intervention program.