Objective To explore the application effect of 7E teaching mode in clinical practice teaching of Surgical Nursing. Methods A total of 157 third-year nursing undergraduates from grade 2017 were selected as the control group by convenience sampling method and taught by the traditional teaching mode. Another 162 nursing undergraduates in grade 2018 were selected as the experimental group，and taught by 7E teaching mode. Results After teaching，the theoretical knowledge，practical skills，total score，score of autonomous learning ability，empathy ability and the positive attitude score of communication skills of the experimental group were better than those of the control group（P<0.05）. There was no significant difference in the negative attitude scores between the two groups （P>0.05）. Conclusion 7E teaching mode can improve the teaching effect of clinical practice，improve students’ independent learning ability and empathy ability，and improve their communication skills and attitudes.