Objective To explore the teaching practice and its effect of ideology and political theory education in the course of Nursing Ethics using the BOPPPS teaching model. Methods A total of 89 nursing undergraduates of class 2021 in their first year were recruited. The course ideological and political theory education were carried out in Nursing Ethics course using the BOPPPS teaching model. The main components in teaching included formulating the objectives of the course ideological and political theory education based on the characteristics of the course，combined with the characteristics of students，combined with the requirements of professional personnel training. Then，a library of ideological and political cases was developed. After that，the ideological and political activities in the theoretical teaching，practical teaching and the second classroom with online courses as the carrier was carried out. Results About 97%（86/89） of the students evaluated the effect of ideological and political teaching as "very satisfied" or "satisfied". Process evaluation results of students were good and above，and the test paper scores were 100% qualified. The practice case of Nursing Ethics was selected as demonstration case of "Ten Education"：curriculum education（full text） in Hunan Province in 2021. Curriculum teacher team has won the first prize of Curriculum Ideological and Political Teaching Competition in the 2022 of the university. Conclusion The positive effects of ideological and political courses of Nursing Ethics was demonstrated，achieving the double effect in professional knowledge and course thought politics.