Objective To develop and preliminarily apply a virtual simulation experiment teaching system in home visit. Methods Based on virtual reality technology，a high-fidelity simulation teaching system for home visiting was developed by the framework of Omaha System of International Standardized Nursing Language and preliminarily applied in 40 undergraduate nursing students. The effect of the system was evaluated from the feasibility （experimental duration） and acceptability（satisfaction）. Results The simulation teaching system was constructed by taking disabled patients combined with chronic diseases as case，and was divided into six modules according to the family visit program. Forty students used it 96 times，and the average length of experiment was 62.6 minutes. Thirty-five students were very satisfied with the system and five students were satisfied. Conclusion The experiment system has good feasibility and acceptability and can provide a reference for the development of virtual simulation experiment teaching in undergraduate nursing education in the future.