Objective To translate the Nurse-patient Therapeutic Communication Scale into Chinese and examine the reliability and validity of the Chinese version of the scale. Methods Brislin translation model was used in literal translation and back translation. Delphi method and pilot survey were used for cultural adjustment and revision. From November to December 2021，562 clinical nurses were conveniently recuited from five grade Ⅲ，Grade A hospitals in Zhuhai and Shenzhen to investigate and evaluate the reliability and validity of the scale. Results The Chinese scale include 48 items. Findings from the exploratory factor analysis revealed three factors including nurse，situation character and patient，which explained 67.319% of the cumulative variance. Cronbach’s α coefficient for the overall scale was 0.846. The average content validity of the scale was 0.96. Conclusion The Chinese version of Nurse-patient Therapeutic Communication Scale is a scientific and practical instrument with good reliability and validity，which can evaluate the therapeutic communication ability of clinical nurses in China.