Objective To construct a progressive innovation and entrepreneurship course system that suitable for nursing undergraduates. Methods According to the ability requirements from easy to difficult，a progressive innovation and entrepreneurship curriculum system was preliminarily constructed by using the literature review，including basic courses（school public elective courses），experimental courses（nursing professional elective courses） and practical courses（nursing professional elective courses）. These courses are carried out throughout the first grade to the third grade. Among them，the first grade mainly cultivates the basic knowledge and thinking of innovation and entrepreneurship，the second grade mainly provides guidance and skill training for participating projects，and the third grade mainly carries out practical training with the help of innovation and entrepreneurship incubation laboratory. Using the Delphi technique，13 teachers and experts with experience in guiding innovation and entrepreneurship competitions were selected to conduct two rounds of correspondence inquiries on the teaching content，course weight，class hours setting，and assessment methods of the course system. Results The recovery rates of the two rounds of expert letter inquiries were both 100%. The Kendall’s W coefficients of the two rounds of expert consultation were 0.146 and 0.181 respectively（both P<0.05）. The constructed curriculum system of innovation and entrepreneurship for nursing undergraduates is as follows：basic course including 9 contents with 30 class hours；experimental course including 17 contents with 32 class hours；practical course including 9 contents with 32 class hours. Conclusion The constructed progressive innovation and entrepreneurship curriculum system for nursing undergraduates is scientific and reliable，which can provide reference for training innovative nursing talents in the future.