Objective To design and explore the effectiveness of the Ideological and Political Education in Medical Nursing. Methods Medical Nursing was designed in four areas，including political literacy，professional literacy，scientific literacy，and humanistic literacy，which were embedded into teaching cases. After teaching practice，semi-structured interviews with 19 nursing students who were randomly selected from the Grade 2019 were conducted to evaluate the effectiveness. Results Students expressed 5 beneficial themes about the ideological and political，including enhancing the professionalism，strengthening the professional beliefs，improving the interest，transforming the way of thinking，and experiencing the spirit of teamwork. In addition，students reported 4 weakness，including lack of in-depth discussion，difficulty in answering question，the existence of ideological and political points similarities，several cases were not practical. The students showed a tendency for real-life examples，videos and pictures materials，and the preferred teaching methods were classroom interaction and role-play in ideological and political education. Conclusion The case-integrated ideological and political education in Medical Nursing turned out to be effective. The students expressed their validation of the teaching method. In the future，we would further improve the quality of the ideological and political education by enriching the elements and integration methods.