Objective To explore the effect of curriculum design and teaching practice of Nursing Clinical Thinking Training for Common Diseases in Chinese and Western Medicine. Methods The elective course of Nursing Comprehensive Skills Training was changed to the compulsory course of Nursing Clinical Thinking Training for Common Diseases in Chinese and Western Medicine. The course content included six modules of clinical diseases（angina pectoris，cerebral hemorrhage，viral hepatitis，diabetes，herpes zoster and COPD） that could reflect the characteristics of integrated Chinese and western medicine，with seven class hours for each module，including three class hours for theory and four class hours for experiment. In addition，three class hours for design experiment and three class hours for experimental assessment. In the disease module，theoretical courses were taught by teachers of traditional Chinese medicine，clinical medicine，basic medicine and nursing. The experimental course employed the progressive standardized teaching case as the main line and carried out teaching in the form of OSCE. A total of 283 third year nursing undergraduates from a Chinese Medicine University in Hunan Province were selected as the participants in implementation. Before and after the teaching，the self-designed Chinese and western medicine nursing thinking ability scale was applied. Results The examination scores of the students were ranged from 65 to 93（81.66 ± 4.62）. Besides，after such teaching，students’ thinking ability of traditional Chinese and western medicine nursing was higher than before（P<0.05）. Conclusion The course of Nursing Clinical Thinking Training for Common Diseases in Chinese and Western Medicine improves the students’ clinical thinking ability of integrated Chinese and western medicine nursing.