Objective To explore the application and effects of ideological and political teaching design in Community Nursing course focusing on professional guidance and innovative thinking training. Methods A total of 68 nursing undergraduates were selected as participants in a university. In the teaching of Community Nursing course，the ideological and political education with professional guidance and innovative thinking training as the core was carried out，which mainly included political identity，national identity，moral cultivation，and professional quality. The professional identity，self-regulated learning ability and innovation ability scales were applied for assessment before and after the intervention. Results After the course，the total scores of student’s professional identity and self-regulated learning ability were higher than those before the course（P<0.05）. Also，the total score and each dimension score of the innovation ability scale were significantly higher than before（P<0.05）. Conclusion The ideological and political education with professional guidance and innovative thinking training as the core can effectively improve professional identity，self-regulated learning ability and innovation ability of nursing undergraduates.