Objective To explore the nursing plan for the removal of internal jugular central venous catheter,standardize the operation behavior of medical staff,and reduce the incidence of discomfort symptoms. Methods Through literature search,quality evaluation,extraction and summary of evidence and expert consultation,a standardized nursing plan for central venous catheter extraction was formulated,mainly including extraction time,evaluation before extraction,key points of extraction operation,precautions after extraction and treatment of complications. A non-synchronous controlled study was conducted. Seventy cases were allocated to the control group from May to June 2021 receiving routine central venous catheter extraction operation process. Another 75 cases in the experimental group from July to August 2021 carried out standardized nursing scheme for central venous catheter extraction. The incidence of pain,bleeding,difficulty in extubation and catheter rupture were compared between the two groups. Results After the intervention,there was significant difference between the two groups in the incidence of pain at the puncture point,bleeding at the puncture point（χ²=4.494,4.116;P<0.05）. There were no significant differences in the incidence of difficult extubation and catheter rupture between the two groups（P>0.05）. Conclusion Carrying out the standardized nursing scheme of central venous catheter extraction can reduce the incidence of related questions,so as to improve the nursing quality of central venous catheter extraction.