Objective To preliminarily develop the Nursing Innovation and Entrepreneurship Social Practice course and to evaluate its effects. Methods The course framework was developed based on the literature review and expert consultation. The course,a specialized elective course for nursing undergraduates,was divided into 11 lessons with 28 credit hours in total（8 for theory and 20 for practice）. In the second semester of the 2020 academic year and the first semester of the 2021 academic year,small-scale teaching was conducted to undergraduates. Course effects were evaluated through innovation and entrepreneurship outputs,examination score,online evaluation and student interviews. Results Twenty-six students took the course. Students submitted 9 innovative designs. Students got a course score of（88.48±1.98）. The course effects score was（92.88±8.87）. Twenty-six students participated in the interview and 4 themes were extracted which were “broaden horizon”“ providing a way to dreams”“power of role models of innovation and entrepreneurship”“improving students’ abilities of innovation and entrepreneurship”. Conclusion This course has improved students’ abilities of innovation and entrepreneurship practice,with a positive evaluation from students,and is worthy of promotion.