The School of Nursing of Guangzhou Medical University aimed to cope with the challenges of ideological and political education in the Nursing Psychology. The school took moral cultivation as the fundamental task,and set the course objectives of Nursing Psychology in combination with professional training requirements and talent training mode. At the same time,the characteristics of students,teaching challenges,course key points,and ideological and political points were integrated and designed. The ideological and political learning resources were constructed and the ideological and political environment was created. The situational experiential teaching activities based on course ideological and political learning resources were carried out. The Nursing Psychology was the ideological and political demonstration course in the college in 2021. The teaching design won the second prize in Guangdong Teaching Innovation Competition. The overall satisfaction of 115 students with the course ideological and political course was 95.7%. 91.3% of the students believed that their cognition of the ideological and political contents of the course had been improved. 93.0% of the students thought that they had an emotional resonance with the ideological and political contents of the course. 90.4% of the students thought that their learning ability and practical ability had been effectively improved.