Objective To explore the effects of the flipping classroom in teaching of the Traditional Chinese Medicine and Prescription Nursing. Methods Online teaching based on flipped classroom was carried out in the whole course of the Traditional Chinese Medicine and Prescription Nursing. A total of 267 students selected the course. According to the contents,the teaching team designed the teaching video script,recorded 67 micro course videos,designed 10 typical cases and 30 research questions to build the online test questions. Before class,the videos,cases,and PowerPoints were put on the platform. Assignments were made and self-learning was directed. During the flipped classroom teaching,students’ learning results were evaluated through the rain classroom software. The difficult and important points were reviewed and explained. Group discussions were organized and case analysis was carried out. A questionnaire was used to investigate students’ evaluation on the flipped classroom teaching. Results Students’ participation in learning and enthusiasm for classroom discussion were very high. The attendance rate of online flipped classroom was 100%,and the overall score of the course was（83.35±5.25）.The students were generally satisfied with the course organization and the teaching methods. 96.30% of the students gave 4 stars or more on this course. The average score of evaluation on teaching level was 4.63. Conclusion Online flipped classroom can break the time and space constraints of learning,and meet the needs of online teaching reform under emergencies such as epidemic situation.