Objective To develop a health education program with “offline lecture + online supervision” and to examine the effects of the program. Methods A total of 92 patients admitted from May 2019 to May 2020 were recruited and assigned to the experimental group. The offline lectures were provided to the patients in the experimental group during their hospitalization. After discharge,the online supervision was provided to supervise the home care. Another 103 patients who were admitted to the hospital from April 2018 to April 2019 were recruited and assigned to the control group and traditional health education was given to them. The quality of discharge education and self-care ability of patients at admission,discharge,1 month after discharge,and 3 months after discharge in the two groups were compared. Besides,the incidence of stoma-related complications within 3 months after discharge was recorded. Results There was no statistically significant difference in the dimensional score of discharge knowledge need contents between the two groups（P>0.05）. The knowledge acquisition dimension score（51.08±2.94）,the teaching skills and effects dimension score（100.37±6.41）,and the education quality total score（152.01±7.96） of patients in the experimental group were higher than those in the control group（P<0.05）. There was an interaction effect between the patient’s self-care ability and time,and the simple effect analysis showed that at the times of discharge,1 month after discharge,3 months after discharge,the self-care ability scores between the two groups were statistically different（P<0.05）. Complications within 3 months after discharge of patients in the experimental group（9.78%） was lower than that of the control group（63.11%）（P<0.05）. Conclusion The “offline lecture + online supervision” can improve self-care ability when patients are at home,reduce the incidence of adverse events in patients with enterostomy,and ensure patient safety effectively.