Objective To examine the effects of objective structure clinical examination（OSCE） on core competence of students majored in foreign-related nursing in higher vocational colleges. Methods The OSCE was developed based on the nursing cases with the clinical nursing process as the main line. The core competence of foreign nursing was the evaluation dimension of OSCE. Six examination stations were established including nursing assessment,nursing diagnosis and plan,emergency nursing,basic nursing,specialized nursing,and health education. The examination was conducted in 105 students in a higher vocational school. Students’ examination performance,examination difficulty,and examination discrimination were evaluated. Examination appraisals from students and teachers were also collected. Results The mean score of OSCE was 72.52±9.50 and followed a normal distribution. The difficulty indexes of each station were 0.62~0.79,and the discrimination indexes were 0.41~0.74. Teachers and students gave high value to the OSCE. Conclusion OSCE can comprehensively assess the core competence of students majored in foreign-related nursing in higher vocational colleges,and had good feasibility and effectiveness.