Objective To explore the effect of the flipped classroom based on small private online course(SPOC) in the teaching reform of nursing management course. Methods Nursing undergraduates from grade 2017 were recruited,there were 81 students in the intervention group and 67 students in the control group. Traditional teaching methods were used in the control group,flipped class teaching method based on the SPOC was used for teaching in the intervention group. At the end of the course,students’ academic performance was compared between the two groups. Besides, students’ classroom performance and learning experience were evaluated among students in the intervention group.Results The students’ attendance rate of the intervention group was 100%,the score of the exercises after the video was(4.12±1.21),the score of the pre-class quiz was(8.21±2.45). The case analysis score of the intervention group was(11.91±2.08),which was higher than the score of the control group(10.51±1.60). The difference between the two groups was statistically significant(t=4.65,P<0.001). The final score of the intervention group was(70.30±5.81),compared with the control group(68.88±4.53),the difference was not statistically significant(t=1.63,P=0.09). Students of the intervention group believe the flipped class based on SPOC can develop the ability of autonomous learning,communication and teamwork,analysis and problem solving. Conclusion The flipped classroom based on SPOC can develop the ability of autonomous learning and the participation rate of students in the classroom,improve students’ ability to solve nursing management problems. students have a good learning experience.