Objective To evaluate the effects of multi-disciplinary nursing project on perioperative safety management for patients aged 80 or above with endoscopic retrograde cholangiopancreatography（ERCP）. Methods Totally 150 patients with ERCP were selected with 72 patients admitted from October 2015 to March 2017 in the control group,and 78 patients admitted from May 2017 to January 2019 in the experimental group. Patients in the control group mainly received the routine care including health education,assessment,making operation plan,and perioperative care. A project management team was established for patients in the experimental group. The team made the plans to manage the perioperative safety problems of patients in the experimental group. The effects were evaluated by comparing the complication rates,adverse event rates and nursing quality improvement in the two groups. Results The perioperative complication rate of patients in the experimental group was 5.1%（4/78）,and the complication rate in the control group was 12.5%（9/72）. There was no statistically significant between the two groups（χ²=2.417,P=0.120）. There were 5 cases（6%）of adverse events in the experimental group and 19 cases（26%） in the control group（χ²=11.119,P=0.001）. After the intervention,the care quality was improved compared with that before the intervention（P<0.05）. Conclusion Safety management based on project managment is effective for ERCP patients with advanced age. It can improve the quality of nursing.