This paper introduced the practice and experience of establishment of stomatology specialty nurses training base in Shandong Provincial Qianfoshan Hospital. The base was developed by the “4M1E” model（man,machine,material,method,environment） which is used for quality management in business. Contents of the base establishment included trainers and trainees,equipment,material,method,and environment aiming to cultivate the general nurses and specialty nurses. At present,the base has passed the preliminary assessment. However,it failed to pass the second assessment due to insufficient hard facilities. This paper summarizes the experience and reflections during the base establishment to provide reference for other medical institutions to build specialty nurses training bases.