Objective To analyze the relationship among perceived social support,self-acceptance and inner peace in patients with colon cancer. Methods A total of 209 patients with colon cancer were selected by convenient sampling from June 2018 to June 2019. The Perceived Social Support Scale,the Inner Peace State Scale and the Self-Acceptance Questionnaire were used. Results The score of perceived social support was（51.43±10.32）,the score of inner peace was（13.12±2.38） and the score of self-acceptance was（24.43±6.28） in patients with colon cancer. Perceived social support （β=0.245） and self-acceptance （β=0.326） had a positive effect on inner peace,which could explain 18.4% of the variance. Perceived social support played a moderating role between self-acceptance and calm mood（β=0.164）,which could explain 4.3% of the variation. Conclusion Active interventions should be undertaken to improve social support level and self-acceptance of patients with colon cancer.