This study formed an online teaching management working group based on the “total quality management” perspectives. We selected multiple online teaching platforms for 16 courses.An online teaching quality management model entitled “all teachers,all students,whole teaching process,management all,round” was built to achieve five objectives including “extensive teaching methods,in-depth teaching contents,humanistic course ideology,enthusiastic learning attitude,and multidimensional course evaluation”. The rate of “very good” of teaching effects evaluated by teachers increase from 17% to 92% in the first week and in the sixth week. The results of students’ interview showed that 90% of the students were satisfied with the online teaching in the first week. The virtual simulation experiment platform can meet the needs of students in the sixth week. The online teaching quality management model based on total quality management guarantees the education and teaching quality of online courses and make it possible for the subsequent development of online teaching and online and offline mixed teaching management.