Objective To explore the effects of interprofessional collaboration in emergency simulation skill training for undergraduates. Methods Fifteen year-four medical students and 14 year-three nursing students took part in the teaching reform voluntarily and they were divided into 5 groups. There were 5 training sessions for interprofessional cooperative simulation emergency skills with 2 hours per session. The emergency cases were given to students two weeks in advance and students were asked to rehearse by themselves. In the class,the instructors introduced the case and randomly selected one group to do the demonstration. Students were guided to do self-evaluation,cross-evaluation,summary,and re-rehearsal. Lastly,all groups took part in the final simulation examination. Results The average score of 29 students was（86.51±9.24）. Among the five aspects of teamwork,the highest score was the team decision-making ability（9.04±1.44）,followed by the interprofessional communication ability（8.75±2.39）. Conclusion The interprofessional emergency simulation teaching can make up the limitations of independent training of each major,stimulate students’ interest in learning,and help medical students and nursing students to clarify the roles and responsibilities of different majors.