Objective To explore the effects of the blended teaching in pressure injury care based on the virtual simulation platform. Methods The blended teaching based on the virtual simulation platform was applied in teaching of pressure injury care for 50 year-two students. The blended teaching included pre-class virtual training,flipped classroom,simulation practice,and post-class online and offline training & innovation design competition in the second classroom. Students’ feedback was analyzed and questionnaires were used to evaluate the effects of the blended teaching. Another 12 teachers had a discussion meeting and provided feedback. Results Before the blended teaching,the frequency that students used the virtual simulation platform was（2.50±1.44） times per person. After the blended teaching,the achievement degrees of teaching objectives were 94%~96%. The rates that students rated the class as excellent were 78%~96%. The rates that students agreed that blended teaching could facilitate their learning were 94%~96%. The teachers agreed that the blended teaching could improve students’ independent learning ability and the teaching effects of combining theory with practice. Such a method increased the academic challenges,difficulty,and depth of the learning. Conclusion The blended teaching based on the virtual simulation platform can help students master the knowledge and skills and help to cultivate students’ self-learning ability,clinical thinking and innovative ability,which can provide experience for the nursing teaching reform.