Objective To explore the application effect of high simulation teaching in the first aid ability training of new nurses.Methods A total of 208 new nurses in 2019 were selected to carry out high simulation teaching training based on clinical real cases（children with wheezing attack）. After the training,Simulation Design Scale （SDS）,Educational Practices in Simulation Scale（EPSS）,Student Satisfaction and Self-confidence in Learning（SSS） were used to evaluate the training effects,and the feelings and suggestions of the new nurses were collected. Results After the training,the comprehensive score of 208 new nurses was（89.67±4.39）,and the qualified rate was 100%. The scores of SDS,EPSS and SSS were 95.5（80,100）,79（67,80）,20（20,25）,32（32,36） respectively. Conclusion The application of high simulation teaching in the training of the first aid ability of new nurses is effective,which is helpful to cultivate the first aid ability of new nurses.