Objective To explore the construction methods of Fundamentals of Nursing as the first-level undergraduate course.Methods The nursing undergraduates took part in the new teaching model. Various teaching methods included online and offline combination and in and outside school combination. The course objectives,course resources,course contents,teaching methods,and evaluation methods were all constructed.Results In recent five years, 16 students have won 9 National Awards for nursing skill competitions and 354 research papers have been completed. Students have provided 182 nursing services for 5 communities and collected 2,249 copies of residents' health record. The students have written 482 reports. The average scores of students ranged from 71~76. More than 90% of the students gave a high evaluation on this course. They agreed that the course was helpful to the theory learning and skill training. The course can broaden their vision on nursing and improve the communication ability.Conclusion After continuous construction, the course of Fundamentals of Nursing has achieved good teaching results. Students accept it greatly, but it still needs to be continuously improved.