Objective To explore the effects of “wisdom classroom” applied in the Fundamentals of Nursing in a vocational school.Methods Nursing students of Chengdu health school were selected. Students of two classes were included in the experimental group and taught by the “wisdom classroom”. The teaching was conducted through interactive teaching system,E-book package learning system,smart teaching assistant,cloud-based learning platform and other information means by combining with the flipped classroom teaching mode. Students of the other two classes were included in the control group,and the traditional teaching method was used involving theory teaching and demonstration.Results The performance of students in the experimental group was significantly higher than that in the control group for two semesters,except for the midterm performance of the first semester.Conclusion “Wisdom classroom” can improve students’ learning experience and improve their performance. It is suggested that in the middle and later stages of “wisdom classroom”,special attention should be paid to the continuous consolidation of teaching effects and the cultivation of students’ comprehensive ability;in the process of implementation. Besides,we should pay attention to the integration of other teaching methods to maximize the strengths of the teaching.